Greater Manchester moves to England's highest alert, while Wales begins a 17-day lockdown later.
It will include a top level of measures more rigorous than those south of the border.
Pubs, restaurants and non-essential shops will shut when the 17-day lockdown starts at 18:00 BST.
Rhys James and his three friends were kept in isolation in a Florence Covid facility for two months.
A National Audit Office survey found employers asked staff to work while collecting furlough pay.